Vrednotenje peptida tetrakozaktida v galenskih izdelkih za izvedbo hitrega testa ACTH
Evaluation of tetracosactide peptide in galenic formulations for rapid ACTH test

slovenian

2024

volume 75, issue 3

Slovensko farmacevtsko društvo
(Obvezni izvod spletne publikacije)

Tetracosactide is a synthetic analog of the human adrenocorticotropic hormone (ACTH) that stimulates the release of cortisol from the adrenal cortex. There are several functional tests available to assess the adrenal cortex function: rapid and multi-day ACTH tests, insulin tolerance test, metyrapone test and dexamethasone tests. In the rapid ACTH test, cortisol secretion from the adrenal glands is stimulated by injecting tetracosactide. The resulting cortisol level is compared to the baseline ACTH level before the test. If the cortisol level does not increase 30– 60 minutes after the application, it indicates adrenal cortical atrophy. In Slovenian hospitals and outpatient clinics, tetracosactide solution with a concentration of 5 µg/mL is most often prepared in a glass vial. In 2016, the Central Pharmacy of the University Medical Centre Maribor started with the aseptic preparation of tetracosactide solution filled in syringes at the request of hospital departments. The industrial drug was diluted in sodium chloride solution under aseptic conditions. To perform a rapid ACTH test, it is sufficient to load the patient with 1 µg of tetracosactide. The article describes a pharmacopoeial method for the evaluation of tetracosactide and the use of stateof-the-art analytical methods that could be used to evaluate tetracosactide final preparations.

24.10.2024