Poti razgradnje celičnih sestavin
Degradation pathways of cell ingredients

slovenian

1999

volume 38, issue 1

Autophagocytosis    Phagosomes    Ultrastructure    Lysosomes    Lysosomal storage diseases 

Društvo Medicinski razgledi
(Obvezni izvod spletne publikacije)

The degradation of cell ingredients takes place mainly in lysosomes. The most important and also the best known degradation pathway is autophagy, where a sequestrating membrane separates a part of the cytoplasm so forming an autophagic vacuole. Degradation of the autophagic vacuole ingredients starts after the fusion of the autophagic vacuole with a lysosome. Some cytosolic proteins are introduced to a lysosome by a heat-shock protein (Hsp 70) in a process called carrier mediated proteolysis. Another pathway of lysosomal protein degradation is crinophagy where the secretory vesides containing newlysynthesised proteins fuse with the lysosomal membrane instead of fusing with the plasma membrane. Part of the proteolysis is localised in the cytosol and is known as nonlysosomal proteolysis. In this degradation, large protein complexes proteasomes and protein ubiquitin are involved. The degradation products are reused for the synthesis of new cell components. Thus degradationprocesses are involved in recycling of the cell ingredients.

02.07.2015