{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-UKAZJJQT/a381e882-53d4-4317-96a1-6bc872780a38/PDF","dcterms:extent":"115 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-UKAZJJQT/511ed6d8-1129-46cf-b361-2f98e0d1374a/TEXT","dcterms:extent":"19 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-UKAZJJQT","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"1999","dc:creator":["Pšeničnik, Majda","Veranič, Peter"],"dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:38"},{"@xml:lang":"sl","#text":"str. 83-90"}],"dc:identifier":["ISSN:0025-8121","COBISSID:10159833","URN:URN:NBN:SI:doc-UKAZJJQT"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"en","#text":"Autophagocytosis"},{"@xml:lang":"sl","#text":"celice"},{"@xml:lang":"sl","#text":"citologija"},{"@xml:lang":"sl","#text":"lizosomi"},{"@xml:lang":"en","#text":"Lysosomal storage diseases"},{"@xml:lang":"en","#text":"Lysosomes"},{"@xml:lang":"en","#text":"Phagosomes"},{"@xml:lang":"sl","#text":"razgradnja"},{"@xml:lang":"en","#text":"Ultrastructure"},{"@rdf:resource":"http://www.wikidata.org/entity/Q901955"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Poti razgradnje celičnih sestavin| Degradation pathways of cell ingredients|"},"dc:description":[{"@xml:lang":"sl","#text":"The degradation of cell ingredients takes place mainly in lysosomes. The most important and also the best known degradation pathway is autophagy, where a sequestrating membrane separates a part of the cytoplasm so forming an autophagic vacuole. Degradation of the autophagic vacuole ingredients starts after the fusion of the autophagic vacuole with a lysosome. Some cytosolic proteins are introduced to a lysosome by a heat-shock protein (Hsp 70) in a process called carrier mediated proteolysis. Another pathway of lysosomal protein degradation is crinophagy where the secretory vesides containing newlysynthesised proteins fuse with the lysosomal membrane instead of fusing with the plasma membrane. Part of the proteolysis is localised in the cytosol and is known as nonlysosomal proteolysis. In this degradation, large protein complexes proteasomes and protein ubiquitin are involved. The degradation products are reused for the synthesis of new cell components. Thus degradationprocesses are involved in recycling of the cell ingredients"},{"@xml:lang":"sl","#text":"Razgradnja mnogih celičnih sestavin poteka v lizosomih. Ena od poti, po katerih vstopajo snovi v lizosome, je avtofagija. V tem procesu se manjši del citoplazme omeji od ostale celice z membrano (sekvestrirajoča membrana) in tako se oblikuje avtofagna vakuola oziroma avtofagosom. Vsebina avtofagosoma se razgradi po združitvi z lizosomom. Citosolne beljakovine, ki vsebujejo specifično signalno zaporedje, vstopajo v lizosome selektivno ob sodelovanju šapronov (Hsp 70). Krinofagija pa je pojav, pri katerem se vezikli z novo sintetiziranimi sekrecijskimi beljakovinami namesto s plazmalemo zlijejo z membrano lizosoma. Najpomembnejša selektivna razgradnja beljakovin poteka izven lizosomov v citosolu natančneje v beljakovinskih kompleksih imenovanih proteasomi. Pri tem sodeluje beIjakovina ubikvitin, s katerim se označijo kratkožive citosolne in jedrne beljakovine. Produkti, ki nastajajo pri različnih oblikah razgradnje, se uporabijo za izgradnjo novih sestavin celice.Razgraditveni procesi tako sodelujejo pri ponovni uporabi snovi v celici"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-UKAZJJQT","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-UKAZJJQT"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-UKAZJJQT/a381e882-53d4-4317-96a1-6bc872780a38/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-UKAZJJQT/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-UKAZJJQT"}}}}