Urinski zunajcelični vezikli kot potencialni biološki označevalci za odkrivanje okvare presajene ledvice
Urinary extracellular vesicles as potential biomarkers for detecting kidney allograft injury

slovenian

2025

Narodna in univerzitetna knjižnica
(Obvezni izvod spletne publikacije)

Kidney transplantation remains the most effective treatment for end-stage kidney disease and offers better quality of life and longer survival compared to dialysis. Despite advances in transplantation medicine, early detection of allograft injury remains a challenge. The current diagnostic gold standard—biopsy—is invasive, subject to variability in the interpretation of histologic changes and often not representative of the entire graft status. This underscores the growing need for reliable, non-invasive biomarkers that enable timely detection of rejection and more effective monitoring of allograft function. Extracellular vesicles (EVs), small membrane-bound particles released by cells to mediate intercellular communication, are emerging as promising biomarkers. Their molecular cargo reflects the physiological state and origin of the parent cells, and they are present in various body fluids, including urine - a readily available and non-invasive sample. Urinary extracellular vesicles (uEVs) therefore offer a compelling opportunity for real-time insight into the status of the transplanted kidney. This review highlights the diagnostic potential of uEVs in kidney transplantation, focusing on their biogenesis, isolation methods, molecular characteristics, and their emerging role in the early detection of allograft rejection.

28.05.2026