Medsebojni vpliv estrogenov in mikrobioma prebavil in rodil
Interaction of estrogens and the microbiome of the gastrointestinal and female reproductive tract

slovenian

2023

volume 92, issue 7/8

dysbiosis   endometriosis   estrobolome   estrogens   microbiota   ß-glucuronidase

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

According to recent findings, gut microorganisms play a role in physiologic processes such as regulating metabolism, energy homeostasis, immune response, and maintaining intestinal integrity. Microbial communities that inhabit a particular environment, an ecological niche, are defined as microbiome. With the help of the oestrobolome, i.e., bacterial genes that can metabolize conjugated oestrogens, the gut microbiome can regulate oestrogen levels in the systemic ciculation. Oestrogens and other steroid hormones play an important role in regulating the composition and function of microorganisms that colonize the female reproductive tract. The dominance of Lactobacillus genus in the female reproductive tract is consistently associated with favourable reproductive and perinatological outcomes. Disturbances of both microbiomes and dysregulation of oestrobolome can lead to the development of chronic inflammatory (endometriosis) as well as malignant gynaecological diseases (endometrial cancer).

05.04.2024