Laparoscopic radical prostatectomy does not cause significant tissue ischemia
Laparoskopska radikalna prostatektomija ne povzroča pomembne ishemične okvare

english

2006

volume 75, issue 12

Capillaries   Catalase   Glutathione Peroxidase   Ischemia   Laparoscopy   Pathology   prostate   Prostatectomy   Prostatic Neoplasms   Superoxide Dismutase   Surgery   Urinary Incontinence

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background Today, laparoscopic radical prostatectomy is cz commonly used operation with patients suffering from prostatic carcinoma. In contrast to theclassic open radical prostatectomy, the laparoscopic approach is more patient-friendly, whereas long-term results are similar with both methods. CO2which is being insufflated during laparoscopic radical prostatectomy at a pressure of 12-14 mm Hg, could cause ischemic disorder of tissue in operating field. Patients and methods The research group consisted of 44 patients with prostatic carcinoma, coming from the Department of Urology of General HospitalSlovenj Gradec; they were treated with laparoscopic radical prostatectomy, namely the Montsouris technique. The control group however, consisted of 11 patients with prostatic carcinoma from the Department of Urology of the Maribor Teaching Hospital. They were treated with a classic retropubic radicalprostatectomy. Besides clinical data andpathological examinations, patientsfrom both groups were examined for activity of GSH-Px, SOD and CAT enzymes in the venous blood before the operation and immediately after it. After the operation we also took a tissue sample of eachpatientš bladder neckfor immune histochemical and morphometrical examination of open capillary surface. Results Patients of both groups were clinically comparable.Those, treated with the laparoscopic method hacllonger operating time than patients treated with the classic approach (219:140 min.), there wasalso a lower blood loss (33:542), shorter analgesic therapy (3.2: 6.5 days), shorterperiod of urinary catheterisation (5.3:14.7 days). Patients treated laparoscopically, had no statistically notable change in the activity of GSH-Px, SOD arccl CAT enzymes in the venous blood after the operation in comparison to the activity before the operation. (Abstract truncated at 2000 characters)

16.09.2009