Vodikov sulfid - signalna molekula s terapevtskim potencialom
Hydrogen sulfide - a signaling molecule with therapeutic potential

slovenian

2025

volume 76, issue 5

cytochrome c oxidase   hydrogen sulfide   neurodegenerative diseases   vasodilation

Slovensko farmacevtsko društvo
(Obvezni izvod spletne publikacije)

Hydrogen sulfide, along with carbon monoxide and nitric oxide, is an important signaling molecule that is endogenously synthesized by specific enzymes. It is involved in various physiological processes, including vasodilation, neuromodulation, and neuroprotection. Its role in protecting cells from oxidative stress is significant, and research has shown that it also regulates apoptosis and cell proliferation. Additionally, hydrogen sulfide has anti-inflammatory properties, although in some contexts, it may exert pro-inflammatory effects. Despite its many beneficial actions, it is toxic at high concentrations, as it inhibits cytochrome c oxidase, disrupting the respiratory chain, promoting the formation of reactive oxygen species, and leads to cellular damage. hydrogen sulfide donors show potential for treating conditions such as myocardial ischemia, neurodegenerative diseases, and inflammatory disorders; however, their mechanisms of action and safety profiles require further investigation.

20.05.2026