Determination of copper and other trace elements in serum samples from patients with biliary tract cancers : prospective noninterventional nonrandomized clinical study protocol

Contibutor(s)

Reberšek, Martina (author)
Hribernik, Nežka (author)
Kozlica, Katarina (author)
Marković, Stefan (author)
Uršič Valentinuzzi, Katja (author)
Čemažar, Maja (author)
Zuliani, Tea (author)
Milačič Ščančar, Radmila (author)
Ščančar, Janez (author)

Language

english

Source

Radiology and oncology (Ljubljana)

Year

2024

Numbering

volume 58, issue 2

Publisher

Croatian Medical Association - Croatian Society of Radiology
Slovenian Medical Society - Section of Radiology

Provider

Društvo radiologije in onkologije
(Obvezni izvod spletne publikacije)

description

Background Biliary tract cancers (BTCs) are usually diagnosed at an advanced stage, when the disease is incurable. Currently used tumor biomarkers have limited diagnostic value for BTCs, so there is an urgent need for sensitive and specific biomarkers for their earlier diagnosis. Deregulation of the homeostasis of trace elements is involved in the carcinogenesis of different cancers, including BTCs. The objective of the study is to determine/compare the total concentrations of copper (Cu), zinc (Zn) and iron (Fe) and the proportions of free Cu and Cu bound to ceruloplasmin (Cp) and the isotopic ratio of 65Cu/63Cu in serum samples from healthy volunteers and cancer patients using inductively coupled plasma-mass spectrometry-based methods (ICP-MS).

Rights

URN

URN:NBN:SI:DOC-BXEMOIHI

COBISSID

192145667

DOI

10.2478/raon-2024-0026

Added

06.06.2025

Metadata

Citation

APA:

Reberšek, Martina, Hribernik, Nežka, Kozlica, Katarina, Marković, Stefan, Uršič Valentinuzzi, Katja, Čemažar, Maja, Zuliani, Tea, Milačič Ščančar, Radmila, Ščančar, Janez (2024). Determination of copper and other trace elements in serum samples from patients with biliary tract cancers. Radiology and oncology (Ljubljana), volume 58, issue 2, str. 300-310, XIV. URN:NBN:SI:DOC-BXEMOIHI from http://www.dlib.si

MLA:

Reberšek, Martina, Hribernik, Nežka, Kozlica, Katarina, Marković, Stefan, Uršič Valentinuzzi, Katja, Čemažar, Maja, Zuliani, Tea, Milačič Ščančar, Radmila, Ščančar, Janez. "Determination of copper and other trace elements in serum samples from patients with biliary tract cancers." Radiology and oncology (Ljubljana) volume 58. issue 2 (2024) str. 300-310, XIV.
<http://www.dlib.si/?URN=URN:NBN:SI:DOC-BXEMOIHI>

Radiology and oncology
1992-
(Assembly record)