Slikanje SPECT dopaminskega prenašalca pri boleznih možganov
SPECT imaging of dopamine transporter in brain disorders

slovenian

2008

volume 77, issue 9

Dementia   diagnosis   Diagnostika   Movement Disorders   Parkinson Disease   Tremor

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background. Diagnosis of parkinsonism is based on medical history and clinical examination. When the signs of parkinsonism are obvious (tremor at rest, rigidity, bradykinesia), the diagnosis is relatively easy. However, problems appear when clinical signs are not typical or distinct enough for making the proper diagnosis. Dopamine transporter imaging with radioactive tracer 123I-Ioflupane (DAT-SPECT) enables a clear evaluation of nigrostriatal degeneration and helps a clinician to make a correct diagnosis. This article discusses the role and indications of DAT-SPECT imaging in patients with movement disorders and in patients with dementia. Conclusions. DAT-SPECT enables clear differentiation of degenerative parkinsonisms from parkinsonisms and non-parkinsonian tremors in which the nigrostriatal pathway remains intact. DAT-SPECT also differentiates dementia with Lewy bodies from Alzheimer's disease.

16.09.2009