50 KB111 KB28 KB192920262008Flisar, DušanGrmek, MarkoPuklavec, LudvikTrošt, Maja6 straniletnik:77številka:9str. 635-640ISSN:1318-0347COBISSID:3097663URN:URN:NBN:SI:doc-4GEK45EJslSlovensko zdravniško društvoZdravniški vestnikDemencaDementiadiagnosisDiagnostikaMotnje gibanjaMovement DisordersParkinson DiseaseParkinsonova bolezenslikovna diagnostikaSPECTTremorSlikanje SPECT dopaminskega prenašalca pri boleznih možganov| SPECT imaging of dopamine transporter in brain disorders|Background. Diagnosis of parkinsonism is based on medical history and clinical examination. When the signs of parkinsonism are obvious (tremor at rest, rigidity, bradykinesia), the diagnosis is relatively easy. However, problems appear when clinical signs are not typical or distinct enough for making the proper diagnosis. Dopamine transporter imaging with radioactive tracer 123I-Ioflupane (DAT-SPECT) enables a clear evaluation of nigrostriatal degeneration and helps a clinician to make a correct diagnosis. This article discusses the role and indications of DAT-SPECT imaging in patients with movement disorders and in patients with dementia. Conclusions. DAT-SPECT enables clear differentiation of degenerative parkinsonisms from parkinsonisms and non-parkinsonian tremors in which the nigrostriatal pathway remains intact. DAT-SPECT also differentiates dementia with Lewy bodies from Alzheimer's diseaseIzhodišča. Diagnozo parkinsonizma postavimo na osnovi anamneze in kliničnega pregleda. Kadar so znaki parkinsonizma jasno izraženi (tremor v mirovanju, rigor, bradikineza), je diagnoza enostavna. Težave se pojavijo, ko klinični znaki niso značilni ali dovolj izraziti. Slikanje SPECT dopaminskega prenašalca z radioaktivnim označevalcem 123I-Ioflupanom (DAT-SPECT) omogoča zanesljivo oceno degeneracije nigrostriatalne poti in pomaga kliniku k pravilni diagnozi. Članek obravnava vlogo in indikacije slikanja DAT-SPECT pri bolnikih z motnjami gibanja in pri bolnikih z demenco. Zaključki. Slikanje DAT-SPECT omogoča zanesljivo ločevanje degenerativnih parkinsonizmov od parkinsonizmov in neparkinsonskih tremorjev, pri katerih je nigrostriatalna pot ohranjena. DAT-SPECT loči tudi demenco z Lewyevimi telesci od Alzheimerjeve bolezniTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo