Novejša spoznanja na področju presnove lipoproteinov
Recent advances in lipoprotein metabolism

slovenian

2022

Narodna in univerzitetna knjižnica
(Obvezni izvod spletne publikacije)

Cardiovascular diseases are still the leading cause of death in the world. There are many risk factors for their development; one of the most important is dyslipidemia (increased or decreased lipoprotein levels). Dyslipidemias can be caused by certain diseases (secondary), but most often they are due to the interaction of genetic and environmental factors (primary). The paper describes lipoprotein metabolism pathways involving a number of lipoprotein receptors, membrane transporters, enzymes, and transport proteins. We have known many of them for a long time, but new ones are being discovered. Understanding the molecular and genetic mechanisms of lipoprotein metabolism is the basis for exploring the pathophysiology of dyslipidemias and has important clinical applications. New drugs are being developed that can be used in combination with statins to lower serum LDL-cholesterol and further reduce the risk of cardiovascular disease (the case of the PCSK9 inhibitor). Greater knowledge of lipoprotein metabolism will in the future open possibilities for targeted individualized treatment of dyslipidemias.

17.01.2025