Vloga cisteinske peptidaze katepsina X pri polarizaciji celic mikroglije
Role of cysteine peptidase cathepsin X in microglia polarization

slovenian

2025

volume 76, issue 3

cathepsin X   cathepsin X inhibitor   inflammation   microglia   polarization

Slovensko farmacevtsko društvo
(Obvezni izvod spletne publikacije)

Microglia are glial cells of the central nervous system, similar to macrophages, which maintain homeostasis of the brain and are among the most important cells of the innate immune system of the central nervous system. Under the influence of pathological and immunological stimuli, a polarization of microglia occurs, either into the proinflammatory phenotype M1, which promotes the processes of neuroinflammation, or into the antiinflammatory phenotype M2, which exhibits a protective function in the brain. Cysteine cathepsins, which are released by polarized microglia of the M1 phenotype are increasingly recognized as important inflammatory factors that trigger signaling pathways that further promote inflammatory processes and lead to neurodegeneration. These include the cysteine peptidase cathepsin X, which has already been recognized as a pathogenic factor in inflammation-induced neurodegeneration, but whose role in the polarization of microglia into a specific phenotype is still unknown. The obtained results suggest that cathepsin X plays an important role in the polarization of microglia into the proinflammatory M1 and the anti-inflammatory M2 phenotype and thus represents a potential therapeutic target for the prevention and treatment of neurodegenerative diseases associated with excessive inflammation.

20.05.2026