Paraneoplastic dermatomyositis associated with testicular cancer : a case of report and literature review

english

2010

volume 19, issue 1

Združenje slovenskih dermatovenerologov
(Obvezni izvod spletne publikacije)

Dermatomyositis (DM) is frequently associated with neoplastic disorders, mainly carcinomas. However, the association of DM with testicular cancer appears to be very rare. A 37-year-old male was treated for a skin rash on theface and arms with pronounced itching. In December 2005, a testicular swelling and ulceration appeared and a unilateral orchiectomy was performed after a diagnosis of seminoma testis was made. However, the skin rash worsenedand symmetric muscle weakness appeared in February 2006. The patient was admitted to the Department of Dermatology, Medical University of Sofia, with characteristic heliotrope erythema, eyelid edema, erythematous plaques onthe upper chest, and Gottron's papules on the wrists. Severe muscle weaknesswas found in the proximal limb muscles. The patient's creatine kinase level was significantly elevated, whereas ASAT and ALAT were within normal ranges. Electromyography and skin biopsy supported a diagnosis of DM. Treatment with moderate corticosteroids and a short course of azathioprine markedly improved the skin lesions and muscle weakness. Even in young patientswith DM, the risk of neoplasm is increased. Early recognition of the characteristic skin rash may provide a clue to the diagnosis, and screening for neoplasm may improve the prognosis.

11.04.2014