Multiple primary malignancies in patients with lung cancer

english

2005

volume 39, issue 1

Lung Neoplasms   Neoplasms, Multiple Primary   Prognosis   tumor

Društvo radiologije in onkologije
(Obvezni izvod spletne publikacije)

Background. To evaluate the incidence of multiple prirnary malignancies in lung cancer patient`s, we summarized our experience in lung cancer patients with multiple primary malignancies. Methods. A total of 1194 consecutive Lung cancer patients, who were admitted to our division over a 29 year period up toAugust 2004, were retrospectively analyzed. Results. Ninety-eight (8.2`) of 1194 lung cancer patients had multipte prirnary malignancies. Metachronous malignant disease comprised 77.6% and synchronous 21.4%. Multiple primary tumours in our patients were detected rnore frequent in the advanced stage of lung cancer (IIIA-IV 67.3%) than in the early stage (IA-IIB 32.7%). The histological examination of lung cancer revealed a preponderance of squamous cell carcinoma (40 patients, 40.8%). First primary tumours developed most commonly in gastrointestinal tract, fallowed by lung and uterus. Fifty-seven (85.1%) of 67 patients with aerogastrointestinal and head and neck cancers hada smoking habit. In 98 patients with multiple primary cancers, forty (40.8%) patients had stage IA-IIIA lung cancer, however, 26 (26.5%) had a surgical resection. Conclusions. Existing metachronous primary tumours proved to be a worse prognostic factor in non-small cell lung cancer patients (p=0.0480), while synchronous primary turnours were not, as well as there was not proven that multiple primary tumours were worse prognostic factors in patients with small cell lung cancer.

16.09.2009