Polielektrolitni kompleksi kot osnova za razvoj novih nanodelcev in nanooblog
Polyelectrolyte complexes as a platform for development of novel nanoparticles and nanocoatings

slovenian

2016

volume 67, issue 4

drug 

Slovensko farmacevtsko društvo
(Obvezni izvod spletne publikacije)

Polyelectrolyte complexes are based on ionic interaction between the charged polymer (polyelectrolyte) and the substance with the opposite charge, which can be a polymer, a protein, a surfactant or any other charged substance. Active pharmaceutical ingredients that fall in any of the aforementioned categories, can be incorporated into these complexes based on the electrostatic interaction, or can be simply physically entrapped into the complex during its formation. The polyelectrolyte complex formation is spontaneous, although it is important to take into the consideration many different parameters that can affect it. Amongst them the most important one is the charge ratio of the components, which has crucial impact on the colloidal stability of the formed complexes. This concept of complexation can be used in the development of functional polymer drug delivery systems, where the nanodelivery systems are very well investigated, w here polyelectrolyte complexation can enable the controlled drug release, the protection of the drug from degradation or targeted drug delivery.

12.02.2019