Uspehi zdravljenja akutne limfoblastne levkemije odraslih s protokolom UKALL XII na Hematološkem oddelku v Ljubljani
Treatment of acute lymphoblastic leukemia in adults with UKALL XII protocol

slovenian

2008

volume 77, issue 1

Adult   Drug Therapy   Leukemia, Lymphocytic, Acute   Survival Analysis   therapy   Treatment Outcome

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background The prognosis of acute lymphoblastic leukemia (ALL) in adults is far worse than that in children in terms of induction of complete remision (61-85%) and leukemia-free survival 3-5 years (35%). The UKALL XII regiment was studied at the Department of Haematology, Universitiy Medical Centre Ljubljana. Patients and methods Between January 2000 and December 2007 41 adults patients with newly diagnosed ALL were eligible for induction chemotherapy (UKALL XII regiment). The median age of the patients was 33 years, range 17-68 years. We conducted 18 hematopoietic cell transplantation (HCT), including 9 avtologous, 5 related donor HCT and 4 unrelated donor HCT. Results 33 patients (81%) achieved complete remission. Overall 5-year survivalin all patients was 48%. In those younger than 30 years in was 66% andin those older than 30 years it was 38%. 4 patients (10%) died within 6 weeks of diagnosis. The cause of mortality proved to be infection. ConclusionsThe UKALL XII regiment is an aggressive approach. We conclude that cytogenetics is a strong independent prognostic factor. In most patients we can achieve a complete remission, but most patients relapse. Therefore allogeneic HCT or prolonged consolidation and maintainance tretment is warranted. There is probable no benefit of avtologous HCT in patients with ALL.

16.09.2009