Sodobna uporaba analize zunajceličnih nukleinskih kislin v laboratorijski medicini
Contemporary use of cell-free nucleic acids analysis in laboratory medicine

slovenian

2010

volume 61, issue 3

Slovensko farmacevtsko društvo

Cell-free nucleic acids are nucleic acids in plasma, serum or in cell-free fraction of various others biological fluids. Their analysis offers noninvasive inspection of the tissue or organ of their origin. The paper reviews contemporary use of quantitative and qualitative analysis of cellfree nucleic acids in laboratory medicine. The first part sumarises chronologic development of major analytical approaches to cell-free nucleic acids analysisin the case of medical assessment of lung cancer patients. The second part presents the use of cell-free nucleic acids analysis in noninvasive diagnosis of gene and genome alterations of the fetus and diseases and complications of pregnancy. The last part indicates the prominent examples of its use in the other areas of laboratory medicine. Cell-free nucleic acids analysis in laboratory medicine means a novel research tool, an interesting professional challenge and alternative or supplement to protein analysis.

30.07.2012