Zdravljenje otrok z astmo z enim ali dvema dnevnima odmerkoma inhalacijskega kortikosteroida : ocena učinkovitosti zdravljenja in vpliva na rast otrok
Once-daily or twice-daily delivery of inhaled corticosteroids : assessment of the efficacy and of influence of the long term treatment on growth in asthmatic children

slovenian

2006

volume 75, issue 3

Administration And Dosage   Administration, Inhalation   Asthma   Body Height   Child   Drug Therapy   Glucocorticoids, Synthetic   Peak Expiratory Flow Rate   therapy

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background Inhaled corticosteroids are recommended drugs for asthma treatment.Their growth suppressive potential is well-known. Twice-daily delivery is usually used in children, but poor compliance of such long-term treatment may represent a problem which can be resolved with once-daily regimen. The aim of this prospective study was to asses the efficacy and the influence on growth of long term once-daily administration of inhaled fluticasone propionate (FP) in asthmatic Slovene children under 5 years. Methods Children with mild persistent asthma took part in parallel group trial. Their parents recorded asthma symptoms, beta2-agonist usage, and PEF using a form for asthma control on a daily basis for a period of one year. According twice or once-daily treatment they were divided in two groups: groupA - children receiving FP 100microg twice-daily and group B children receiving FP 200microg once-daily at bedtime. Mean height of 26 children of the same sex and age from each group and of 26 healthy children (groups A1, B1, C) was observed. Chi-square analysis with Yates' correction and t tests were employed for between - group analyses (SPSS software 11.0). Results FP given once-daily was as effective and tolerated as the same total dose given twice-daily. PEF, asthma symptoms and bronchodilator use of children from group B were not significantly different from those from group A (p > 0. 05). The mean height increase of children receiving FP once-daily was smaller for 0.22 cm than of children receiving FP twice-daily and for 0.98 cm than of healthy children (t = Z.56 p = 0. Z32; DF: 24). Conclusions Once-daily administration of inhaled FP in asthmatic children is safe and as effective astwice-daily administration. The suppressive potential is greater when it is given once-daily.

10.04.2014