Ali je možno na osnovi sestave aterosklerotičnih leh karotidnih arterij napovedati možganskožilne dogodke?
Is it possible to estimate cerebro-vascular risk on the basis of the composition of carotid atherosclerotic plaques?

slovenian

2012

volume 81, issue 2

Atherosclerosis   Carotid Stenosis   Cerebrovascular Disorders   Diagnosis   Magnetic Resonance Imaging   Risk Factors   Tomography, Emission-Computed   Tomography, X-Ray Computed   Ultrasonography

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Different models for the prediction of cardiovascular and cerebro-vascular events are used, based on the presence of risk factors. This is a statistical risk-assessment model. Recently, research has been focused on identifying indicators that would enable us to directly assess the risk in certain individuals. These indicators include the detection of the presence and composition of atherosclerotic plaques. Atherosclerotic plaques found in a majority of adults represent a potential cause of vascular complications. Recently, not only the stage of atherosclerotic plaques or the degree of arterial stenosis but also the knowledge of atherosclerotic plaque compositionis gaining in importance. Particularly unstable plaques, which are prone to disintegration and the associated thromboembolic complications, are considered dangerous. Therefore, recently intensive research has been underwayto find methods that would enable us to identify the composition and in particular the biological activity of atherosclerotic plaques. Namely, the latter two features determine the stability of plaques or their proneness to rupture and disintegration. While classical angiography is invasive and associated with irradiation, it only provides information on the degree of vascular lumen stenosis but not also on vascular wall composition. Ultrasonography is a basic non-invasive imaging method, which also provides aninsight into the composition of vascular wall, however, since mainly superficially situated arteries are accessible by US, its investigation potential in distinguishing between different tissue structures is rather limited. Recent computer programs for analysis of ultrasound images and quantifying various components of atherosclerotic plaques provide a more accurate determination of the composition of atherosclerotic plaques, but do not yield information on the biological activity of atherosclerotic lesions. (Abstract truncated at 2000 characters)

14.08.2013