Napredni dostavni sistemi učinkovin za preventivo in zdravljenje parodontalne bolezni
Advanced drug delivery systems for prevention and treatment of periodontal disease

slovenian

2019

volume 70, issue 2

Slovensko farmacevtsko društvo
(Obvezni izvod spletne publikacije)

Periodontal disease causes reduced adhesion of dental tissue to the tooth root, and gradual decomposition of the periodontal ligament, cementum, and alveolar bone, with occasional pain and discomfort on chewing, and eventual tooth loss. This paper provides an update on the approaches to periodontal disease treatment, for reduction of periodontal plaques and periodontopathogenic microorganisms, modulation of immunomodulatory response, and regeneration of periodontal tissues. Advanced delivery systems in the fight against periodontal disease are gaining in importance, and include nanosized carriers for small drug molecules, biopharmaceutics, probiotics, or stem cells. Furthermore, nanodelivery systems with their specific features are designed to improve the bioavailability of the therapeutics over that achieved by conventional dosage forms. Indeed, the nanomedicines can enable targeted drug delivery to periodontal pockets, to specific cells and cellular organelles, or to microorganisms in biofilms. Additionally, the nanocarriers can control the release of the incorporated therapeutic(s). The most studied advanced drug delivery systems for treatment of periodontal disease are liposomes, polymeric nanoparticles, and nanofibers, which are reviewed here. Special focus is on nanofibers, in which can be incorporated drug molecules and probiotics, as well as represent a scaffold for regenerative cells to achieve better regeneration of periodontal tissues in the future.

10.06.2020