Možnosti terapevtske uporabe nanodelcev s strukturo tekočih kristalov kot dostavnih sistemov zdravilnih učinkovin
Therapeutic possibilities of liquid crystalline nanoparticles as drug delivery systems

slovenian

2025

volume 76, issue 5

administration routes   cubosomes   hexosomes   lipid-based delivery systems   liquid crystals   nanoparticles   preparation methods

Slovensko farmacevtsko društvo
(Obvezni izvod spletne publikacije)

Liquid crystalline nanoparticles are thermodynamically stable nanodelivery systems with an ordered structure, combining the properties of crystalline matter and liquids. Their unique structure enables incorporation of hydrophilic, amphiphilic, and hydrophobic active pharmaceutical ingredients. Their protection, controlled release, and enhanced bioavailability are the most common advantages of liquid crystalline nanoparticles, which can be tailored for various routes of administration. In oral delivery, active pharmaceutical ingredients are incorporated into liquid crystalline nanoparticles to improve their absorption and bioavailability, protect unstable active pharmaceutical ingredients, or prevent their side effects. For dermal application, controlled release and enhanced permeability of active pharmaceutical ingredients into deeper tissue layers are key advantages. Moreover, liquid crystalline nanoparticles enable targeted therapy for cancer and brain diseases and offer new opportunities for the delivery of vaccines and biological active substances such as proteins, peptides, and nucleic acids. however, clinical translation of these nanoparticles is hindered primarily by burst release kinetics and a lack of biorelevant models and studies. Despite these challenges, liquid crystalline nanoparticles represent a versatile delivery platform with the potential to develop accessible and patient-friendly medicines.

20.05.2026