Staphylococcus aureus, nosilec gena za Panton-Valentine leukocidin, in letalna nekrotizirajoča pljučnica pri mladem imunokompetentnem bolniku
Lethal necrotising pneumonia in young imunocompetent patient caused by Staphyloccocus aureus carrying gene for Panton-Valentine leukocidin

slovenian

2006

volume 75, issue 12

Adult   Community-Acquired Infections   Fatal Outcome   Genetics   Isolation And Purification   Leukocidins   Pneumonia, Bacterial   Staphylococcus Aureus

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background Staphylococcus aureus (S. aureus) is a major cause of hospital-acquired infections. It secretes many exotoxins, in less then 5% alsoPanton-Valentine leukocidin (PVL). S. aureus carrying PVL genes is mainly associated with necrotic lesions of skin and mucosa and can cause severe necrotising community-acquired pneumonia. Methods We describe a case of a 30 year-old patient with a history of furunculosis who was admitted to our hospital with atypical lower abdominal pain. A clinical picture of acute abdomen developed and he was operated with no intraabdominal pathology found. A periprocedural respiratory insufficiency and later septic shock developed. S. aureus and Streptococcus pneumoniae were isolated from blood cultures and tracheal aspirate. In spite of all measures taken, high ventilatory support and targeted antibiotic treatment, severe pulmonary dysfunction with bilateralpneumothorax developed and the patient died of respiratory failure. Later genes encoding PVL were found in the isolated strains of S. aureus. Conclusions Severe progressive necrotising pneumonia with high mortality can be caused by PVL positive S. aureus in imunocompetent patients. To prevent thefuture spread of PVL positive S. aureus infection, the measures as known for methicillin-resistant S. aures, should probable be taken.

16.09.2009