Impact of systemic psoriasis treatment on the lesional T-lymphocyte subtypes

english

2002

volume 11, issue 2

Združenje slovenskih dermatovenerologov
(Obvezni izvod spletne publikacije)

Objective In 19 patients suffering from severe psoriasis and who were treated by Cyclosporin A (CyA), CD4 and CD8 positive T cells were studied. Materials and methods. Skin from affected areas was examined by immunohistopathology forthe presence of CD4 and CD8 positive T cells before and 4 weeks after the start of treatment. Results. Significant decrease in CD4 positive T cells and a non-significant decrease in CD8 positive T cells were observed after the initiation of treatment. CD4/CD8 ratio dropped from the values of 2.10 to 1.68. Dramatic decrease in PASI score was observed, from the average value of 23.34 to that of 11.97. Discussion. The authors compare and discuss the results of a few similar cytophotometric studies found in the available literature. The decreases in T lymphocyte subsets correlate with clinically wellknown treatment effect of CyA and suggest underlying immunopathologic process.

16.09.2022