Uspešnost zdravljenja okužbe z bakterijo Helicobacter pylori v Sloveniji v letu 2008
Cumulative Helicobacter pylori eradication rates in Slovenia in the year 2008

slovenian

2010

volume 79, issue 1

Clarithromycin   Cross-Sectional Studies   Diagnostic Use   Drug Therapy   Duodenal Ulcer   Gastritis   Helicobacter Infections   Helicobacter Pylori   Helicobacter, infekcije   Metronidazole   Omeprazole   Stomach Ulcer   therapy   Treatment Outcome   Urea

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background: The aim of the study was to examine cumulative Helicobacter pylorieradication rates in Slovenia in the year 2008 that can be achieved in clinical practice by clasic first and second regimens suggested by Maastricht recommendations and third line empirical regimens. Methods: We performed crosssectional study that included 500 consecutive patients, who underwent urea breath test aft er Helicobacter pylori eradication regimens in AM DC Rogaška in the period from January to September 2008.We analysed eradication rates after OMC regimen, 7 days (omeprazole, metronidazole, clarithromycin), OAC regimen, 7 days (omeprazole, amoxicillin, clarithromycin), BMTO regimen, 14 days (colloid bismuth subcitrate, metronidazole, oxytetracycline, omeprazole) and OA regimen, 14 days (omeprazole, amoxicillin). Results: Total 308 patients received OMC regimen with eradication rate 78.6 % (95 % CI 76.3%-80.9%). Total 80 patients received OAC regimen with eradication rate 80% (95 % CI 75.6 %-84.4 %). After failure of the first regimen, they receivedthe opposite first-line regimen. In the case of eradication failure, 23 patients received BMTO regimen as a third-line therapy with eradication rate 82.6 % and 14 patients received OA regimen with eradication rate 64.3 %. Nine of 388 patients who started Helicobacter pylori eradication treatment in our study remained positive aft er they received all the available therapeutical regimens (2,3 %). Conclusions. Cumulative Helicobacter pylori eradication rate in Slovenia in the year 2008 is still very high-97.7 %. Theseresults are comparable with the results in other European countries.

17.06.2010