Contact hypersensitivity to selected excipients of dermatological topical preparations anf cosmetics in patients with chronic eczema

english

2008

volume 17, issue 2

antioxidant   Antioxidants   Dermatitis, Contact   Eczema   Excipients

Združenje slovenskih dermatovenerologov
(Obvezni izvod spletne publikacije)

Objective: 1) Assessment of the frequency of contact sensitization to selectedexcipients of dermatological topical preparations and cosmetics in patients with chronic eczema. 2) Detection of the sources of sensitization. Methods: 1,927 patients with chronic eczema (mean age 44.3 years, 601 males, 1,326 females) were patch tested with selected excipients. Results: The main rates of sensitization observed were: thiomersal 11.3%, wool alcohols 4.0%, phenylmercuric acetate 3.1%, formaldehyde 2.5%, dodecyl gallate 2.0%, Bronopol1.9%, dibromodicyanobutane/phenoxyethanol (1:4) 1.7%, chloracetamide 1.6%, chlorhexidine digluconate 1.5%, Kathon CG 1.4%, parabens 1.1%, diazolidinyl urea 0.9%, imidazolidinyl urea 0.7%, benzalkonium chloride 0.7%, and Quaternium-15 (quaternary ammonium salt) 0.7%. Conclusion: The rate of sensitization to the excipients included in dermatological topical preparations and cosmetics in patients with chronic eczema is significant. Complete information on all the ingredients is necessary.

11.04.2014