Uropatogena Escherichia coli - priložnostni znotrajcelični parazit
Uropathogenic Escherichia coli - an opportunistic intracellular parasite

slovenian

2008

volume 47, issue 3

Bladder    Pathology    Urothelium    Cystitis    Escherichia Coli 

Društvo Medicinski razgledi
(Obvezni izvod spletne publikacije)

The majority of urinary tract infections are caused by strains of uropathogenic Escherichia coli. One of the characteristics of urinary tract infections is the high frequency of recurrence, usually caused by the same bacterial line causing the primary infection. The results of a recent study revealed that the reason for recurrent infection lies in residual bacteria that persist in latent form inside uroepithelial cells after the acute primaryinfection. In the endosomal vesicles of urothelial cells, uropathogenicEscherichia coli is thus protected from both the immune system and most antibiotics. It has also been found recently that uropathogenic Escherichia coli spends most of its lifetime inside terminally differentiated urothelial cells. The most important factors of successful proliferation of uropathogenic Escherichia coli were found to be the ultrastructural characteristics of these differentiated cells, such as the disappearance of actin filaments from the subapical region of urothelial cells. Uropathogenic Escherichia coli seems to exit urothelial cells only to be disseminated to other uninfected cells. The recent discovery of uropathogenic Escherichia colias an intracellular parasite indicates new treatment modalities for recurrent cystitis.

24.06.2015