Anteriorna ishemična optična nevropatija kot posledica zdravljenja z interferonom alfa
Anterior ischemic optic neuropathy secondary to interferon alpha

slovenian

2005

volume 74, issue 10

Adverse Effects   Drug Therapy   Fundus Oculi   Hepatitis C   Interferon-alfa   Interferon-Alpha   Middle Age   Optic Neuropathy, Ischemic   Therapeutic Use   therapy

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background. Anterior ischemic optic neuropathy rarely occurs with interferon alpha therapy. The mechanism by which interferon induces anterior ischemic optic neuropathy is unknown. Methods. A 62-year-old man presented with complaints of sudden severe loss of vision in the left eye. He has been receiving interferon alpha and ribavirin for chronic infection with hepatitis C virus. Vision loss occurred 6 months after the beginning of treatment. Afterwe ruled out other possible etiologies, a diagnosis of anterior ischemic optic neuropathy due to interferon therapy was made and the drug was discontinued. A follow up 3 weeks later showed an improvement of visual acuityand resolution of scotoma, disc hemorrhage and edema. Conclusions. The resolution of anterior ischemic optic neuropathy after discontinuation of interferon suggested a casual relation, though the pathophysiologic mechanism remains unknown. An ophthalmologic examination should be performed in patientswith risk factors of visual loss before and regularly during interferon treatment.

10.04.2014