Resni neželeni učinki zdravljenja kronične levkemije z zaviralci tirozinske kinaze : prikaz primerov in pregled literature
Severe adverse effects associated with tyrosine kinase inhibitors therapy in chronic myeloid leukaemia : case reports and literature review

slovenian

2011

volume 80, issue 5

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background: Chronic myeloid leukaemia is a clonal myeloproliferative disorder of myeloid progenitor cells. The availability of moleculartargeted therapy with tyrosine kinase inhibitors has changed the course and treatment for patients with chronic myeloid leukemia. The long-term follow-up of adverse events amongst the kinase inhibitors played role in forming decision- making algorithms for the use of this highly effective group of therapeutics. Patients and methods: In this paper, four CML patients are presented, treated with different tyrosine kinase inhibitors. Haematologic toxicity of kinase inhibitors is the most frequent adverse effect; however, non-haematological adverse effects should also not be neglected. Conclusions: Tyrosine kinase inhibitors have changed the therapy of CML, the treatment of these patients isa long-term process. Therefore, to know adverse effects is the matter of great importance in order to promptly recognise them and treat them properly.

30.01.2012