Simulating the digestion of lipid-based drug delivery systems (LBDDS): overview of in vitro lipolysis models

english

2014

volume 61, issue 1

Slovensko kemijsko društvo
(Obvezni izvod spletne publikacije)

One of the greatest challenges in the pharmaceutical science is the improvement of oral bioavailability of poorly solub- le drugs. Lately, one of the most attractive approaches has been formulation of lipid based drug delivery systems. Howe- ver, the emerging popularity of these systems in the last decade has brought to light the need for efficient methods for their in vitro evaluation that would serve as their in vivo behaviour prediction tool. Because lipids are subject to lipid di- gestion and multiple absorption pathways in vivo , simple dissolution tests are not predictive enough when testing lipid based delivery systems. To assert these needs, the in vitro lipolysis model has been developed, utilizing pancreatic enzy- mes, bile and phospholipids in a temperature controlled chamber to simulate in vivo digestion. However, with very va- riable physiological conditions in gastrointestinal tract, this model has not been yet standardised and experiments vary among different laboratories. This review discusses in vivo events following oral application of lipid based delivery, in vitro lipolysis models to emulate them and their future perspectives.

13.05.2015