Ojačitev in glajenje kalcijevih celičnih signalov s primerjavo prenosa signalov v tehniki : doktorska disertacija

english
slovenian

doktorska dela

2008

Univerza v Mariboru, Fakulteta za naravoslovje in matematiko

The doctoral thesis is in the field of cellular signalling. It is theoretically investigated the cellular signalling, which is based on protein cascades activated by an increased intracellular calcium concentration. In particular, it is analysed the role of protein cascades in smoothening of cellular signals with short reaction time and the role of protein cascades in amplification of signals which should preserve their form. An analogy with signal transduction in electrical engineering systems is conducted. The behaviour of biological systems is directly compared with known solutions in electrical engineering systems. In the thesis two main original scientific contributions are presented. First, it is shown that smoothening of oscillatory signals with fast on-off characteristics can be realised by a small number of cascade levels. Second, cascade amplifiers are also appropriate for amplifying signals which should preserve their form. This is a successful solution in biological as well as in electro engineering systems.

08.08.2023