Conservative treatment of anal canal cancer : retrospective study

english

1997

volume 31, issue 2

Neoplasm staging   Rectal neoplasms   Treatment outcome

Onkološki inštitut Ljubljana

Between January 1981 and May 1996, thirty partients with anal canal carcinoma were treated with a protocol of radiation therapy alone or in combination withchemotherapy. The patients were divided into 4 stages by International Union against Cancer (UICC) 1987: I stage 8 patients, II stage 16 patients, III stage 5 patients, nobody in stage IV and 1 patient in recurrence. Sixteen patients were treated with external radiation therapy alone, 8 with interstitial 192Ir implant alone, and 6 with the combination of both (dose range 30-70 Gy). Nine patients received concomitant cytotoxic chemotherapy. Toxicities were mild to moderate. Twenty-eight patients were eligible and 2 were lost to follow-up. A complete response (CR) was observed in 19 patients (68%); nobody of these patients had local recurrence and anorectal function was retained. We may conclude that radiotherapy with or withot chemotherapy can provide a good local control and preserve anal function with acceptable morbitidy.

10.11.2023