Vloga hrane v glikaciji in lipoksidaciji končnih produktov in pri nastanku vnetnih mediatorjev
The role of food in glycation and lipoxidation of end products and - amplifiers of inflammation

slovenian

2008

volume 77, issue 4

chronic condition   Chronic Disease   Diet   Glycosylation   Inflammation Mediators   Lipid Peroxidation   Oxidative Stress

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background Today chronic diseases (ChD) constitute the leading cause of morbidity and mortality. They are clearly associated with our lirestyle, and with consumption of cheap processed agricultural products, which affect the function of the immune system, and the inflammatory response. The non-enzymatic pathway for glycation of dietary products plays an important role in the pathogenesis of ChDs, particularly diabetes, and metabolic syndrome. Oxidative stress with lipid peroxidation, and protein glycation havebeen associated with atheriosclerosis, cancer prevention and therapy, endocrine, gastrointestinal disorders (such as liver cirrhosis and steatosis as well as with inflammatory bowel disorders), pulmonary disorders, rheumatoidarthritis amd other skeletomuscular, and skin diseases. By far fhe greatest of contributors of dietary advansed glycation end products (AGE) seemto be dairy products, bread and meat. Conclusions General caloric restriction, restriction in intake of processed agricultural foods, cautious vitamin, antioxidant, pre- and probiotics supplementation seemed to be effective ways to extend life span. However, exaggerated inflammation is also observed in patients, who suffer acute diseases; infections, trauma and advanced surgical and medical treatments such as transplantations. Complications and sequelae to these events are significantly more common in elderly and particularly in those with ChDs. There is a lot of evidence that the lifestyle of the elderly and particularly in those with ChDs. There is a lot of evidence that the lifestyle of the patients and degree of inflammation before trauma significantly affects outcome.

16.09.2009