Nova spoznanja o reninsko-angiotenzisko-aldosteronskem sistemu in nove strategije njegove zavore
New knowledge of renin-angiotensin-aldosterone system and new strategies of its blockade

slovenian

2008

volume 47, issue 4

Renin-Angiotensin System    Aldosterone    Angiotensins    Hypertension    Angiotensin-Converting Enzyme Inhibitors   Receptors, Angiotensin   Antagonists And Inhibitors   Receptors, Mineralocorticoid

Društvo Medicinski razgledi
(Obvezni izvod spletne publikacije)

The renin-angiotensin-aldosterone system is a hormone system chat is vital forthe regulation of arterial blood pressure, electrolyte balance and extracellular fluid volume in the body. Since the discovery of renin in 1898 and later the renin-angiotensin-aldostcronc system, there have been numerous studies on its effects and influences on physiological and pathophysiological mechanisms in different organs. The classical renin-angiotensin-aldosterone system pathway that begins with the release of renin from the kidneys, throughangiotensin-I, angiotensin-II and aldosteroneformation is a widely known concept that could now be described as incomplete. There is increasing evidence of the existence of a tissue renin-angiotensin-aldosterone system butit has been unsatisfactorily blocked with the blocking strategies known to dace. The objective of this paper is to address new knowledge about the renin-angiotensin-aldosterone system and new strategies for its blockage.

24.06.2015