Zaloge železa v telesu pri bolnikih, zdravljenih s transfuzijami eritrocitov
Iron body stores in patients treated with red-cell transfusions

slovenian

2007

volume 76, issue 7/8

C-Reactive Protein   Erythrocyte Transfusion   Ferritin   Leukemia   Receptors, Transferrin   Therapy

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background Consequence of chronic transfusion therapy is a secondary iron overload, which adversely affects the heart, liver and endocrine glands. This can be minimized by iron chelating therapy. The assessment of iron overload isessential to assign and adjust this treatment. Serum ferritin is a widely used marker for the estimation of iron stores. However, a variety of conditions alter the relationship between serum ferritin levels and body iron stores. Soluble transferrin receptors in serum (sTfR) reflect the degree of erythropoiesis and the status of body iron. The data on usage of serum transferrin receptors for the assessment of iron overload are sparse. The purpose of our work was to estimate iron overload in transfusion dependentpatients and to assess the combinative value of serum transferrin receptors and ferritin in prediction of iron load. Methods Serum levels of iron, transferrin saturation, ferritin ctnd sTfR were evaluated for 36 transfusion dependent patients. Twenty of them had myelodysplastic syndrome (MDS). Body iron (mg/kg) was calculated from the sTfR/ferritin ratio with the use of regression formula developed by Cook et al. Levels of serum parameters and calculated body iron were compared with estimated iron overload. We used absolute number of transfused units of blood as a measure of iron overload. (Abstract truncated at 2000 characters)

16.09.2009