Clinical images An unusually large squamous cell carcinoma mass arising from the lower lip An unusually large squamnous cell carcinoma mass arising from the lower lip A. Feily, N. Pazyar, E. Rafeie, A. Khazanee, and M. R. Namazi KEY WORDS squamous cell carcinoma, lip Squamous cell carcinoma (SCC) of the lip is a relatively common malignancy of the head and neck region (1). Tumor thickness, grading, and perineural invasion are significant prognostic indicators (1). We report an 81-year-old, otherwise healthy woman presenting with a huge friable mass originating from her lower lip. The lesion had started as a small papule 8 years before. It later became eroded and ul- cerative and transformed into a slow growing, flesh-colored mass that began interfering with her speaking and eating. Radiologic studies showed no evidence of bone involvement. The lesion was diagnosed his-topathologically as squamous cell carcinoma. The patient was advised to undertake palliative treatment such as surgery or chemotherapy, but she refused any intervention. references 1. Somma P, Lo Muzio L, Mansueto G, Delfino M, Fabbrocini G, Mascolo M, Mignogna C, Di Benedetto M, Carinci F, De Lillo A, Pastore L, Serpico R, De Rosa G, Staibano S. Squamous cell carcinoma of the lower lip: FAS/FASL expression, lymphocyte subtypes and outcome. Int J Immunopathol Pharmacol. 2005 Jan-Mar;18(1):59-64. Acta Dermatoven APA Vol 19, 2010, No 3 authors' Amir Feily, MD, Resident of Dermatology, Department of Dermatology, addresses Jondishapur University of Medical Sciences, Ahvaz, Iran Nader Pazyar, MD, Resident of Dermatology, same address Esmaeil Rafeie, MD, Resident of Dermatology, same address Ahmad Khazanee, MD, Resident of Dermatology, same address Mohammad Reza Namazi, MD, Assistant Professor of Dermatology, Medicinal and Natural Products Chemistry Research Center and Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran, corresponding author, E-mail: namazi_mr@yahoo.com - 43 An unusually large squamous cell carcinoma mass arising from the lower lip Clinical images examination of the mass. 44 Acta Dermatoven APA Vol 19, 2010, No 3