ANNALES KINESIOLOGIAE • 1 • 2010 • 1 1 FOREWORD The exponential increase in our knowledge of the cellular and sub-cellular mecha- nisms of life, made possible by a similar rise in the “dissecting power” of current ana- lytical tools, has rendered the more traditional fi elds of integrative and system physiol- ogy somewhat outdated, particularly so in the eyes of our younger colleagues who often label these disciplines “paleophysiology”. I think that this era is now giving way to a more sober approach, in which the information gained at the molecular, sub-cellular and cellular levels is integrated, or at least tentatively so, into a comprehensive view that takes into account everything from tissues, organs and systems, up to the conscious man. It is obvious that this transcends the possibilities of individual scientists; it can only be achieved if large groups from different areas cooperate and exchange methods, results, and ideas. This exchange has now become extremely fast and effi cient thanks to the numerous technological tools available. Even so, the more traditional printed jour- nals are, in my opinion, an invaluable basis whereupon to lay the foundation of Science. Annales Kinesiologiae is a paradigmatic example of such a journal. The content of the present issue, dedicated as it is to Kinesiometrics, i.e. to the study of human motion or, more specifi cally, to its quantitative measurement, is an ostensive defi nition thereof. Indeed, it ranges from a methodological defi nition of the fi eld (P. Blahus), to its applica- tion in several physiological or patho-physiological conditions (W. Zhu, M. Narici, N. Šarabon, R. Pišot, G. Biolo, I. B. Mekjavić); from specifi c technical tools (B. Simunič, M. Tušak), to general methodological aspects (F. Prot, K. Kovar). In this general frame, I have taken the liberty of changing the content of my presentation at the meeting which gave birth to this issue from a specifi c aspect of human muscular function (the bilateral defi cit), to a more general discussion of the philosophical meaning of the scientifi c adventure, based on the history of human powered fl ight. It also worth noting that the acronym of the Institute for Kinesiology Research, IKARUS, coincides perfectly well with the topics of my contribution. IKARUS is spe- cifi cally dedicated to Sports and Environmental Physiology, and, under the leadership of Rado Pisot and of his excellent colleagues, it has the potential to fl y not like a human powered aircraft but like a modern ultrasonic jet. Udine, 8th June, 2010 Pietro Enrico di Prampero