16 KB210 KB15 KB199220252006Haroske, GünterKaatz, M.Köstler, ErichKroenert, C.Schmalenberg, H.Schönlebe, JacquelineSchreiber, G.Wollina, Uweletnik:15številka:2str. 79-84ISSN:1318-4458COBISSID:21593817URN:URN:NBN:SI:doc-ZB0MDOFFenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticadermatologijaHistiocitoza Langerhansovih celicHistiocytosis, Langerhans-Cellkožne bolezniKožne manifestacijePathologySkin ManifestationsTherapyCutaneous Langerhans cell histiocytosis with subsequent development of haematological malignacies| report of two cases|Adult cutaneous Langerhans cell histiocytosis (LCH) is a rare disease. We report two cases illustrating the variability of the clinical presentation andthe response to treatment. In both cases a remission was achieved: in one case a partial remission with psoralen plus UVA irradiation (PUVA) and methotrexate plus topical corticosteroid ointment; in the other case by treatment with thalidomide. Despite a therapeutic response, both patients later developed haematological malignancies: a chronic myelo-monocytic leukaemia and an acute lymphatic leukaemia. In conclusion, patients with adultcutaneous LCH should be monitored carefully so that a secondary malignancy is not overlookedTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov