161 KB39 KB199420252008Bunc, MatjažHawlina, SiminKogoj, Poloncaštevilka:letn. 47str. 31-42ISSN:0025-8121COBISSID:24462041URN:URN:NBN:SI:doc-Z8OW2ALPslMedicinski razglediMedicinski razglediArachidonic AcidArahidonska kislinaCarbon MonoxideDušikov oksidendotelijEndotelij žilniEndotelin-1EndoteliniEndothelin-1EndothelinsEndothelium, VascularNitric OxideOgljikov monoksidožiljeRenin-Angiotensin SystemRenin-angiotenzin, sistemUrotensinsUrotenziniVasoconstrictionVasodilationVazodilatacijaVazokonstrikcijažilni endotelijOd endotelija odvisno uravnavanje žilnega napona|The endothelium is an inner layer of the vascular wall which can produec vasoactive mediators alone or in response to various types of stimuli. Endothelium derived vasoactive substances can cause either endothelium dependent vasoconstriction or vasodilatation, and they play a significant rolein intrinsic vascular tone regulation. By acting an different pathways of intracellular signaling, endathelin-1 and some arachidonic acid metabolites lead to an increased calcium concentration in vascular smooth muscles that finally leads to constriction. Endothelium dependent vasorelaxants in include nitric oxide, carbon monoxide, prostacyclin, endothelium derived hyperpalarizing factor and endocannabinoids. In addition, studies have recently revealed that tire vascular endothelium is responsible for the syrnthesis of a novel cyclic: peptide termed urotensin-II, which exhibits vaseactive properties. Urotensin-II was originally isolated from the fish neuroseeretor organ, but later on various isoforms of this peptide have also been identified in other animal species and in humans. Urotensin-II and its G-protein coupled receptor are widely represented in different tissues, including the v ascular wallTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi