14 KB163 KB13 KB199820252002Breznik, MatejPlaninšek, OdonSrčič, Stankoštevilka:2letnik:498 stranistr. 357-364COBISSID:1161329ISSN:1318-0207URN:URN:NBN:SI:doc-YSW7F1W4enSlovensko kemijsko društvoActa chimica slovenicafizikalne lastnostimagnezijev stearatmetil oranžpraškiStudy of particle interactions in a physical mixture of Mg stearate and methylorange| Študij fizikalnih zmesi Mg-stearata in metiloranža|It is of great interest to pharmaceutical technologists to be able to predict interactions between particles in mixtures in order to predict their behaviourduring technological processes and to control the pharmacokinetic andpharmacodynamic properties of the resulting dosage forms. In our study we used Mg stearate and methyl orange as model compounds to study the mixing behaviour. As expected, the mixture prepared with mortar and pestle in mass proportion 1Č1 was slightly coloured since Mg stearate particles (white) are covering the methyl orange. Our results show that Mg stearate has a lower surface free energy than methyl orange so, theoretically, particles of Mg stearate are expected to spread over the methyl orange particles. This was confirmed by calculation of spreading coefficients that gave positive spreading coefficients of Mg stearate over methyl orange. FT IR measurements for physical mixtures of Mg stearate and methyl orange in different proportions substantiate the spreading coefficient calculation. The results suggest that Mg stearate has a higher covering capacity at lower weight ratiosin mixtures with methyl orangePoznavanje sil med posameznimi delci sestavin praškov in tabletiranih zmesi jezaradi vodenja tehnoloških procesov in vpliva na farmakokinetske in farmakoduinamske lastnosti različnih zdravilnih oblik za farmacevtske tehnologe odločilnega pomena. Pri študiji smo uporabili metiloranž in magnezijev stearat kot modelni substanci in smo ugotovili, da magnezijev stearat dobro prekriva metiloranž. Rezultati kažejo, da ima Mg stearat nižjo prosto površinsko energijo kot metiloranž, prav tako pa je koeficient razširjanja za Mg stearat in metiloranž pozitiven. Meritve absorpcije dobljenez metodo difuzne refleksije potrjujejo, da Mg stearat prekriva metiloranž, dodatno pa je iz rezultatov razvidno, da Mg stearat v nizkih koncentracijah nepričakovano dobro prekriva metiloranžTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko kemijsko društvo