19 KB188 KB17 KB199220252007Domanovič, DragoslavJeras, MatjažKrašna, MetkaŠvajger, UrbanTomšič, Analetnik:16številka:3str. 105-110ISSN:1318-4458COBISSID:23488729URN:URN:NBN:SI:doc-XESLRZBMenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaBlood PlateletsCelična delitevCelične kultureCell DivisionCells, CultureddermatologijaFibroblastiFibroblastsTrombocitiPlatelet gel stimulates proliferation of human dermal fibroblasts in vitro|Background: Platelet gel is a source of many soluble proteins that can modulate tissue regeneration. Dermal fibroblasts play an important role in tissue remodeling and wound healing. Objective: The study was performed to investigate the influence of platelet gel and its active ingredients on the proliferation of human dermal fibroblasts in vitro. Methods: A fibroblast culture was established from a normal human skin biopsy. Platelet gel was prepared from platelet-rich plasma (PRP) following the addition of calcified thrombin solution. cell proliferation was measured by MTT assay. Results: We showed that platelet gel, PRP, and thrombin stimulate the proliferation of dermal fibroblasts, and that stimulation by PRP is dose dependent. Conclusion:Platelet gel can be used to treat chronic skin defectsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov