{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-X8MUA6N6/9832aca5-4273-4407-a062-d1271c470b44/PDF","dcterms:extent":"585 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-X8MUA6N6/433bba40-e6e4-42a5-9102-b30e9780d44e/TEXT","dcterms:extent":"34 KB"}],"edm:TimeSpan":{"@rdf:about":"2004-2025","edm:begin":{"@xml:lang":"en","#text":"2004"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-X8MUA6N6","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-0I3LSS3I"},{"@xml:lang":"sl","#text":"Slovenian veterinary research"}],"dcterms:issued":"2023","dc:creator":["Çetinkaya, Mehmet Alper","Kaya, Mahir"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:60"},{"@xml:lang":"sl","#text":"str. 205-212"}],"dc:identifier":["DOI:10.26873/SVR-1696-2023","ISSN:1580-4003","COBISSID_HOST:188010755","URN:URN:NBN:SI:doc-X8MUA6N6"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Založba Univerze v Ljubljani"},"dc:subject":[{"@xml:lang":"sl","#text":"Cardiomyopathy, Dilated"},{"@xml:lang":"sl","#text":"Doxorubicin"},{"@xml:lang":"sl","#text":"Rats"}],"dcterms:temporal":{"@rdf:resource":"2004-2025"},"dc:title":{"@xml:lang":"sl","#text":"The diagnostic accuracy of radiographic cardiac indices in the assessment of cardiomegaly and left atrial enlargement in rat with dilated cardiomyopathy: and experimental study|"},"dc:description":{"@xml:lang":"sl","#text":"The purpose of this study was to determine the diagnostic value of the ver-tebral heart score (VHS), radiographic left atrial dimension (RLAD), and vertebral left atrial size (VLAS) in the radiographic evaluation of doxorubicin-induced dilated cardio-myopathy (DCM) in rats. The animals were allocated into two experimental groups, a DCM group (n=100), which received weekly injections of doxorubicin (2 mg/kg per dose intraperitoneally ip) over nine weeks, and a control group (n=18) receiving an appropri-ate volume of 0.9% saline ip. Radiographic cardiac indices (VHS, RLAD, VLAS) were measured two weeks after the final injection, and cardiac morphological parameters (heart weight HW, heart weight:body weight ratio HBW, and heart weight:tibial length ratio HTL) were determined after sacrifice in all surviving rats (17 control and 54 DCM). Correlations were calculated between the indices and parameters, as well as their sen-sitivity and specificity in detecting cardiomegaly and left atrial enlargement (LAE) with the three classifiers (HW?0.96 g, HBW?235, and HTL?201). A powerful negative correla-tion was observed between the indices and parameters (rs?-0.711, P<0.001). Area under the curve values were 0.989 for RL-VHS, 0.992 for DV-VHS, 0.971 for RLAD, and 0.948 for VLAS. The sensitivity and specificity of these indices in detecting cardiomegaly and LAE at the optimal cut-off values were 94.4% and 100%, respectively, at 8.8 vertebrae (v) for RL-VHS and DV-VHS, 96.3% and 94.1% at 1.4v for RLAD, and 94.4% and 88.2% at 2.1v for VLAS. Radiographic cardiac indices offer an accurate and repeatable method for predicting cardiomegaly and LAE in rats with DCM"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-X8MUA6N6","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-X8MUA6N6"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-X8MUA6N6/9832aca5-4273-4407-a062-d1271c470b44/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-sa/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Univerza v Ljubljani, Veterinarska fakulteta"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-X8MUA6N6/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-X8MUA6N6"}}}}