21 KB127 KB19 KB199220252008Arican, OzerKurutas, Ergül Belgeštevilka:1letnik:17str. 12-16ISSN:1318-4458COBISSID:24106201URN:URN:NBN:SI:doc-WOIK8DBAenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaAntioksidantiantioxidantAntioxidantsCatalasedermatologijaGlucosephosphate DehydrogenaseGlukozofosfatna dehidrogenazaKatalazaMalondialdehidMalondialdehydeOksidativni stresOxidative StresspatogenezaSuperoksidna dismutazaSuperoxide DismutaseVitiligoOxidative stress in the blood of patients with active localized vitiligo|Objectives: Vitiligo is an acquired skin disease characterized by white areas on the skin. The pathogenesis of the disease is still unclear. Some findings show that oxidative stress could be an important phenomenon in the pathophysiology of vitiligo. Methods: We evaluated 16 consecutive localized vitiligo patients and 16 healthy controls of a similar age and sex distribution. We measured their indicators of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), glucose 6-phosphate dehydrogenase (G6PD) in erythrocytes, and plasma malondialdehyde (MDA) by spectrophotometry.Results: SOD activities and MDA levels of patients were significantly higher than controls (p < 0.001). CAT and G6PD activities of patients were significantly lower than controls (p < 0.05 and p < 0.001, respectively). Conclusion: Our results confirmed that oxidative stress may play an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on some antioxidant parameters of localized-type vitiligo patientsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov