48 KB243 KB32 KB200520252010Anderluh, Markoštevilka:2letnik:61str. 66-72ISSN:0014-8229COBISSID:2784625URN:URN:NBN:SI:doc-W0WOVSQZslSlovensko farmacevtsko društvoFarmacevtski vestnikantidepresividepresijafarmakoterapijamehanizem delovanjaPregled zdravilnih učinkovin za zdravljenje depresije| Drugs for the treatment of depression|Depressive disorder is the most widespread psychiatric disorder in the world and is predicted to be the leading disease of all developed world in the near future. It is frequently a chronic disease with acute phases and periods of remission. Complex clinical picture makes it hard to diagnose, and as a consequence depression often remains untreated. Pharmacotherapy with antidepressants is the major therapeutic strategy for the management of depression. It is based on numerous hypotheses, which form a complicated scheme of depression etiology. The manuscript presents classification of antidepressants, their mechanism of action, side effects and therapeutic efficiencyDepresivna motnja je najpogostejša duševna bolezen v svetovnem merilu, po predvidevanjih pa naj bi kmalu zasedla prvo mesto po pogostosti med vsemi obolenji v razvitem svetu. Potek bolezni zaznamujejo epizode depresij z vmesnimi remisijami. Zaradi kompleksne klinične slike je pogosto neprepoznana in zato nezdravljena. Farmakoterapija z antidepresivi je poleg psihoterapije glavni pristop za zdravljenje depresivnih motenj. Temelji na številnih hipotezah, ki se dopolnjujejo v zapleteno sliko etiologije bolezni. V prispevku je podana sistematična klasifikacija antidepresivov, njihov mehanizem delovanja, stranski učinki in terapevtska uporabnostTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo