219 KB29 KB200520252016Černe, Darkoštevilka:2/3letnik:67str. 127-133ISSN:0014-8229COBISSID:4081265URN:URN:NBN:SI:doc-VUJ4145SslSlovensko farmacevtsko društvoFarmacevtski vestnikDebelostfruktozahormonimaščobno tkivomolekularni mehanizmimultipla sklerozanevrohormonalni sistemoksidativni stresMolekularni mehanizmi nastanka debelosti s poudarkom na vlogi sistema renin-angiotenzin-aldosteron| Molecular mechanisms of obesity with emphasis on the role of the renin-angiotensin-aldosterone system|In the developed countries obesity is acquiring epidemic proportions, therefore the study of the molecular mechanisms of obesity is an important professional and scientific challenge. The first part of the paper presents the most important physiological basics of utilization of energetic molecules (digestion of nutrients in the gastrointestinal tract, the importance of adipose tissue, cellular metabolism of energetic molecules, fructose metabolism), which are regulated on a systemic level and jointly interrelated by the neurohormonal system. The second part of the paper presents the selected molecular mechanisms of obesity, the role of adipose tissue, the importance of local synthesis of hormones of the renin-angiotensin-aldosterone system and their systemic effects, the role of oxidative stress and the importance of consuming food rich in fructoseDebelost dobiva v razvitem svetu razsežnosti epidemije, zato je preučevanje molekularnih mehanizmov nastanka debelosti pomemben strokovni in znanstveni izziv. V prvem delu prispevka so predstavljene pomembnejše fiziološke osnove izrabe energijskih molekul (prebava hranil v gastrointestinalnem traktu, vloga maščobnega tkiva v energijskem ravnovesju, celični metabolizem energijskih molekul in metabolizem fruktoze), ki jih na sistemskem nivoju uravnava in medsebojno interaktivno povezuje nevrohormonalni sistem. V drugem delu prispevka so predstavljeni izbrani molekularni mehanizmi nastanka debelosti, vloga maščobnega tkiva kot endokrinega organa, pomen lokalne sinteze hormonov sistema renin-angiotenzin-aldosteron in njihovi sistemski vplivi, vloga oksidativnega stresa in pomen uživanja hrane bogate s fruktozoTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo