25 KB87 KB21 KB200220262005Božanić, VinkoFranko-Kancler, TatjanaGrmek-Košnik, IrenaHarlander, TatjanaKavčič, MartinaRibič, HelenaSarjanović, LjudmilaŠtrumbelj, Iztokštevilka:2letnik:44str. 80-84ISSN:0351-0026COBISSID:1387493URN:URN:NBN:SI:doc-VKFRARN8slInštitut za varovanje zdravja Republike SlovenijeZdravstveno varstvoantibioticantibiotikibacteriabakterijemicrobiologymikrobiologijaodpornostStreptococcus pneumoniaeOdpornost izolatov Streptococcus pneumoniae iz dihal v letu 2003| Antimicrobial resistance in Streptococcus pneumoniae isolates in 2003|Objective: To determine resistance to selected antibiotics in respiratory tract isolates of Streptococcus pneumoniae in year 2003. Methods: From January to December 2003, 879 S. pneumonia isolates from the respiratory tractcollected in eight microbiology laboratories in Slovenia were studied fortheir susceptibility to several antimicrobials and for the phenotype of resistance to macrolides. Results: All the isolates tested were susceptible tovancomycin, levofloxacin and moxifloxacin; 16.6% of strains were intermediately resistant and 0.5% were resistant to penicillin. Intermediate resistance to cefotaxim was established in 0.2% of strains, and no resistance in 0%. The rate of resistance to trimethoprim-sulfamethoxazole was 27%, to tetracycline 12.2%, to erythromycin 12.3% and to clindamycin 9.8%. Considerable differences in the rate of resistance to some antibiotics were found between the regions studied. Conclusions: The established rates of resistance to the antimicrobials tested provide the basis for appropriate choice of antibiotic therapy. There were no significant differences in resistance rates between the year 2003 and the previous two yearsNamen: Pri izolatih iz dihal iz leta 2003 ugotoviti delež odpornih izolatov vrste Streptococcus pneumoniae proti nekaterim antibiotikom. Metode: V osmih slovenskih mikrobioloških laboratorijih so v letu 2003 iz dihal osamili 879 izolatov vrste Streptococcus pneumoniae. Pri izolatih so določili občutljivostza izbrane antibiotike in fenotip odpornosti proti makrolidom. Rezultati: Vsi testirani izolati so bili občutljivi za vankomicin, levofloksacin in moksifloksacin. Proti penicilinu je bilo 16,6 % vmesno odpornih in 0,5 % odpornih izolatov, proti cefotaksimu je bilo 0,2 % vmesno odpornih izolatov, odpornih ni bilo. Delež odpornosti proti trimetoprim-sulfametoksazolu je bil 27 %, proti tetraciklinu 12,2 %, proti eritromicinu 12,3 % in proti klindamicinu 9,8 %. Pri nekaterih antibiotikih sobile razlike med regijami precejšnje. Zaključek: Ugotovljeni deleži odpornih izolatov so dobra osnova za racionalno izbiro antibiotičnega zdravljenja. V primerjavi z letoma 2001 in 2002 v letu 2003 ni bilo velikih razlikTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaInštitut za varovanje zdravja RS