28 KB178 KB26 KB200520252013Kikelj, Danijelštevilka:2letnik:64str. 129-136ISSN:0014-8229COBISSID:3441777URN:URN:NBN:SI:doc-VDOLWFGJslSlovensko farmacevtsko društvoFarmacevtski vestnikasthmaastmadrugzdravilaSodobna sintezna zdravila za zdravljenje astme| Modern synthetic drugs for treatment of asthma|Asthma is a chronic airway disorder characterized by airflow obstruction and an underlying inflammation. Asthma symptoms are caused by bronchoconstriction and inflammation, and therapeutical approached are directed at both of these patophysiological problems. The paper brings an overview of modern synthetic drugs for treatment and management of asthma, including bronchoselective adrenergic beta2 agonists, anticholinegics, glucocorticoids, leukotriene biosynthesis inhibitors, leukotriene receptor antagonists and phosphodiesterase inhibitorsAstma je kronična bolezen dihalnih poti, za katero sta značilni brohokonstrikcija in vnetje. Delovanje učinkovin za obvladovanje in zdravljenje astme je usmerjeno prvenstveno proti obema patofiziološkima problemoma. V tem članku podajamo pregled sodobnih sinteznih učinkovin za zdravljenje astme, ki vključujejo bronhoselektivne adrenergične beta2 agoniste, antiholinergične učinkovine, glukokortikoide, inhibitorje biosinteze levkotrienov in antagoniste levkotrienskih receptorjev ter inhibitorje fosfodiesterazTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo