33 KB152 KB32 KB200520252009Brunskole Švegelj, MojcaLanišnik-Rižner, TeaStojan, Jureštevilka:6letnik:60str. 295-302ISSN:0014-8229COBISSID:26425305URN:URN:NBN:SI:doc-V753QGBBslSlovensko farmacevtsko društvoFarmacevtski vestnikantimikotikiglivične bolezniAntimikotiki| Antimycotics| current and novel strategies for treatment of fungal infections| sedanje in nove možnosti zdravljenja glivičnih okužb|Antifungal treatment is becoming more and more important as the incidence of invasive fungal infections is increasing. Currently, several antimycotics withdiverse mechanisms of action are available, but their usage is often limited by their adverse effects and resistance. Novel strategies for the treatment of fungal infections are as follows: high-dose therapy, modulation of the pharmacokinetic properties of the drugs, combination therapy, immune system enhancement, and the development of new antifungal agents. Ideal antimycotics would have selectivity to fungal cells, low rates of resistance, broad antifungal activity, reduced toxicity and improved efficacy. The most promising antifungals are those targeting fungal cell wall components, proteinbiosynthesis and signaling pathwaysTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo