{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-USCDXS4W/db1a1f9c-8bad-4322-951f-6c1f20010c6e/PDF","dcterms:extent":"153 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-USCDXS4W/cf14039b-b63c-46f4-a23a-803e88a3073e/TEXT","dcterms:extent":"36 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-USCDXS4W","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"2001","dc:creator":"Dajčman, Davorin","dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"letnik:40"},{"@xml:lang":"sl","#text":"str. 313-323"}],"dc:identifier":["ISSN:0025-8121","COBISSID:867647","URN:URN:NBN:SI:doc-USCDXS4W"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"sl","#text":"Hepatopulmonalni sindrom"},{"@xml:lang":"en","#text":"Hepatopulmonary syndrome"},{"@xml:lang":"sl","#text":"jetrne bolezni"},{"@xml:lang":"sl","#text":"pljučne bolezni"},{"@xml:lang":"sl","#text":"zapleti"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Hepatopulmonalni sindrom| Hepatopulmonary syndrom|"},"dc:description":[{"@xml:lang":"sl","#text":"Hepatopulmonary syndrome is caused by intrapulmonary vasodilation that leads to abnormal arterial gas exchange in the setting of liver disease or portal hypertension. Hepatopulmonary syndrome results in hypoxemia due to pulmonary vasodilatation with significant arteriovenous shunting and ventilation-perfusion mismatch. It is the most widely recognized of the processes associated with end-stage liver disease and is seen in up to 15% of cirrhotics. Testing for the presence of oxygenation abnormalities and intrapulmonary vasodilation is needed to make the diagnosis. Chronic liver dysfunction is associated with pulmonary manifestations due to alternations inthe production or clearance of circulating cytokines and other mediators. Excess production of nitric oxide in the lung contributes to pulmonary vasodilation. Hepatopulmonary syndrome is an increasingly common indication for liver transplantation because no medical therapies are established as effective"},{"@xml:lang":"sl","#text":"Hepatopulmonalni sindrom je posledica vazodilatacije v pljučnem obtoku, ki poslabša izmenjavo plinov med vdihanim zrakom v alveolih in kapilarami in nastane v sklopu kronične jetrne bolezni ali portalne hipertenzije. Zaradi porušenega razmerja med ventilacijo in perfuzijo in nastanka pljučnih šantov nastopi hipoksemija. Običajno se pojavi pri bolnikih z napredovalo jetrno okvaro, ugotavljajo pa ga pri približno 15% bolnikov s cirozo jeter. Diagnozo potrdijo preiskave o oksigenaciji arterijske krvi in dokazi vazodilatacije v pljučnem ožilju. Vazodilatacija pljučnega ožilja je posledica nepravilnosti v sproščanju in izločanju krožečih citokinov in številnih drugih posrednikov. Okvara jeter preko različnih posrednikov vpliva na povečano sproščanje dušikovega oksida, ki pospešuje vazodilatacijo pljučnega ožilja. Ker do danes še ne poznamo uspešnega zdravljenja z zdravili, je hepatopulmonalni sindrom pogosta indikacija za presaditev jeter"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-USCDXS4W","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-USCDXS4W"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-USCDXS4W/db1a1f9c-8bad-4322-951f-6c1f20010c6e/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-USCDXS4W/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-USCDXS4W"}}}}