{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-UPXULKYC/03e04367-6d1b-47b7-8f64-6e8f6686376f/PDF","dcterms:extent":"113 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-UPXULKYC/ffc40bfa-85b7-45c7-9918-ef664bd07e09/TEXT","dcterms:extent":"75 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-UPXULKYC","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"1999","dc:creator":"Kotnik, Primož","dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:38"},{"@xml:lang":"sl","#text":"str. 167-192"}],"dc:identifier":["ISSN:0025-8121","COBISSID:10798041","URN:URN:NBN:SI:doc-UPXULKYC"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"en","#text":"Administration, inhalation"},{"@xml:lang":"en","#text":"Asthma"},{"@xml:lang":"sl","#text":"astma"},{"@xml:lang":"en","#text":"Child"},{"@xml:lang":"sl","#text":"dihala"},{"@xml:lang":"en","#text":"Drug therapy"},{"@xml:lang":"en","#text":"Glucocorticoids, synthetic"},{"@xml:lang":"sl","#text":"infekcije"},{"@xml:lang":"en","#text":"Respiratory tract infections"},{"@xml:lang":"en","#text":"Therapeutic use"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"sl","#text":"zdravljenje"},{"@rdf:resource":"http://www.wikidata.org/entity/Q7891"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Vpliv protivnetnega zdravljenja z glukokortikosteroidi na število in težo okužb dihal pri otrocih z astmo| Influence of anti-inflammatory therapy with glucocorticosteroids on the frequency and severity of respiratory infections in children with asthma|"},"dc:description":[{"@xml:lang":"sl","#text":"Abstract. Asthma is a chronic inflammatory respiratory disease. Anti-inflammatory therapy with inhaled glucocorticosteroids is considered the most effective long-term therapy for moderate and severe forms of chronic asthma. Side effects constitute the only limitation of this therapy. The purpose of our study was to find out whet- her long-term administration of inhaled glucocorticosteroids for asthma has an imunosupresive side effect. We studied the frequency and severity of respiratory infections in asthmatic children treated with long-term inhaled glucocorticosteroids and in children with asthma receiving no such therapy. Our hypothesis was that long-term therapy with inhaled glucocorticosteroids for asthma has an imunosupressive side effect and that asthmatic children given long-term therapy with inhaled glucocorticosteroids suffer more frequent and more severe respiratory infections than children with asthma receiving no such medication. This one-year prospective study included 20 children with mild and moderate asthma,aged 7 years 0 months to 14 years 11 months (average 9 years, 4 months.There were 7 girls and 13 boys. The children were divided into two groups (n=10): one group receiving long-term therapy with inhaled glucocorticosteroids (fluticasone propionate) and another group given no such therapy. Because of moral, ethical and medical principles a non-random grouping of children was used in this study. (Abstract truncated at 2000 characters.)"},{"@xml:lang":"sl","#text":"Izvleček. Astma je kronična vnetna bolezen dihal. Protivnetno zdravljenje z inhalacijskimi glukokortikosteroidi velja za najbolj učinkovito zdravljenje zmerne in hude kronične astme pri odraslih in otrocih. Edina omejitev za njihovo uporabo so stranski učinki. Z našo raziskavo smo poskusili ugotoviti, ali ima redno zdravljenje otrok z astmo z inhalacijskimi glukokortikosteroidi imunosupresivni stranski učinek. Ocenjevali smo pogostost in težo okužb dihal pri otrocih z astmo, ki se redno zdravijo z inhalacijskimi glukokortikosteroidi, v primerjavi z otroki z astmo, ki se z njimi ne zdravijo. Naša hipoteza je bila, da ima redno zdravljenje otrok z astmo z inhalacijskimi glukokortikosteroidi imunosupresivni stranski učinek. Otroci z astmo, ki se redno zdravijo z inhalacijskimi glukokortikosteroidi imajo pogostejše in težje okužbe dihal kot otroci z astmo, ki se z inhalacijskimi glukokortikosteroidi ne zdravijo redno. Raziskava je bila prospektivna in je trajala eno leto. V raziskavo je bilo vključenih 20 otrok z blago in zmerno astmo, starih od 7 let 0 mesecev do 14 let 11 mesecev (povprečna starost 9 let4 meseci), 7 deklic, 13 dečkov. Razporejeni so bili v dve skupini (n=10). Ena skupina je bila redno zdravljena z inhalacijskimi glukokortikosteroidi (flutikazon propionat), druga ne. Zaradi moralnih, etičnih in strokovnih načelpreiskovancev nismo mogli uvrstiti v skupine naključno. Otroci so, ob pomoči staršev, v dnevnik beležili simptome okužbe dihal in astme ter merili naj- večjo hitrost pretoka zraka pri izdihu in telesno temperaturo. (Izvleček prekinjen pri 2000 znakih.)"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-UPXULKYC","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-UPXULKYC"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-UPXULKYC/03e04367-6d1b-47b7-8f64-6e8f6686376f/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-UPXULKYC/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-UPXULKYC"}}}}