23610 KB0 KB199220252023Dolenc-Voljč, MatejaDolenc-Voljč, MatejaPagon, Andrejaletnik:32številka:iss. 4str. 191-195DOI:10.15570/actaapa.2023.34ISSN:1318-4458COBISSID_HOST:180826883URN:URN:NBN:SI:doc-TM0WWAGJenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et Adriaticaalitretinoindarier diseaseDarierjeva bolezengenodematozagenodermatosisretinoidiretinoidssistemsko zdravljenjesystemic treatmentEfficacy of alitretinoin in the treatment of Darier disease| a case report|Darier disease is a rare autosomal dominant genodermatosis that initially first presents in adolescence with scaly reddish brown keratotic papules and plaques with a seborrheic and intertriginous distribution. The absence of specific targeted medications complicates the treatment process, and managing resistant cases can prove challenging due to recurrent exacerbations that may result in serious complications such as secondary bacterial and viral infections. Treatments of choice include antiseptics, topical corticosteroids, and systemic retinoids, mainly acitretin and isotretinoin. We report the case of a female patient with Darier disease that was unsuccessfully treated with acitretin and isotretinoin but showed significant improvement with alitretinoin. Previous reports on the efficacy of alitretinoin in Darier disease are reviewedTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov